FUSE - Memoirs of the Hunter Girl(2012)

Fuse Teppou Musume no Torimonochou

Hamaji, a young huntress from the mountains, stumbles into the middle of a shogun's vendetta against a group of human and dog hybrids - the Fuse. Rumors of Fuse murdering innocent people in the bustling city of Edo have sparked a bounty for their heads. Hamaji joins the hunt for this dangerous quarry along with her brother, but after accidentally befriending one of them, Hamaji is torn between two worlds: her life as a self-reliant huntress, and the young woman her new friend has helped her to uncover.

(Source: Anime Limited)